Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases
نویسندگان
چکیده
منابع مشابه
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.
We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, re...
متن کاملNew structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.
We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiological pH enables the reactivators to cross the blood-brain barrier and distribute in the CNS aqueous space as dictated by interstitial and cellular ...
متن کاملTryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases.
Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.
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in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...
15 صفحه اولa criical evaluation of prospect 1: iranian junior high school english book
این پایان نامه کتاب زبان انگلیسی پایه هفتم(پراسپکت 1) را بر اساس چک لیست کانینگ ورث (1995) مورد ارزیابی قراردهده و نقاط قوت و ضعب کتاب مذکور را بررسی می نماید. در گام دوم نیز از طریق مصاحبه با تعدادی از دبیران زبان انگلیسی که کتاب مورد نظر را تدریس می کنند، نظر دبیران را در مورد پراسپک 1 جویا می شود.
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2020
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2019.12.016